Cordyceps: Cellular Energy, VO₂ Max & Athletic Performance
An evidence-based breakdown of Cordyceps militaris and Ophiocordyceps sinensis — from cordycepin's AMPK activation and ATP synthesis to peer-reviewed athletic performance trials, antidepressant mechanisms via BDNF upregulation, and blood-sugar regulation. Includes double-blind VO₂ max study results and the ongoing ClinicalTrials.gov mood trial.
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Source Research Papers
Citations in APA 7 format. All studies were sourced from peer-reviewed journals via Google Scholar.
Chen, S., Li, Z., Krochmal, R., Abrazado, M., Kim, W., & Cooper, C. B. (2010). Effect of Cs-4® (Cordyceps sinensis) on exercise performance in healthy older subjects: A double-blind, placebo-controlled trial. Journal of Alternative and Complementary Medicine, 16(5), 585–590. https://doi.org/10.1089/acm.2009.0226
Koh, J. H., Kim, K. M., Kim, J. M., Song, J. C., & Suh, H. J. (2003). Antifatigue and antistress effect of the hot-water fraction from mycelia of Cordyceps sinensis. Biological and Pharmaceutical Bulletin, 26(5), 691–694. https://doi.org/10.1248/bpb.26.691
Nishizawa, K., Torii, K., Kawasaki, A., Katada, M., Ito, M., Nishimura, T., Kobayashi, M., Nemeroff, C. B., & Bhattacharya, S. K. (2007). Antidepressant-like effect of Cordyceps sinensis in the mouse tail suspension test. Biological and Pharmaceutical Bulletin, 30(9), 1758–1762. https://doi.org/10.1248/bpb.30.1758
Tianzhu, Z., Shihai, Y., & Juan, D. (2014). Antidepressant-like effects of cordycepin in a mice model of chronic unpredictable mild stress. Evidence-Based Complementary and Alternative Medicine, 2014, 438506. https://doi.org/10.1155/2014/438506
Ashraf, S. A., Elkhalifa, A. E. O., Siddiqui, A. J., Patel, M., Awadelkareem, A. M., Snoussi, M., Ashraf, M. S., Adnan, M., & Hadi, S. (2020). Cordycepin for health and wellbeing: A potent bioactive metabolite of an entomopathogenic medicinal fungus Cordyceps with its nutraceutical and therapeutic potential. Molecules, 25(12), 2735. https://doi.org/10.3390/molecules25122735
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