Healing With Psilocybin: Clinical Evidence for Lasting Therapeutic Change
A synthesis of the clinical evidence for psilocybin-assisted therapy — covering randomized controlled trial outcomes, neuroplasticity mechanisms including dendritic spine growth, and what long-term follow-up data reveals about the durability of therapeutic change.
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Source Research Papers
Citations in APA 7 format. All studies were sourced from peer-reviewed journals via Google Scholar.
Davis, A. K., Barrett, F. S., May, D. G., Cosimano, M. P., Sepeda, N. D., Johnson, M. W., Finan, P. H., & Griffiths, R. R. (2021). Effects of psilocybin-assisted therapy on major depressive disorder: A randomized clinical trial. JAMA Psychiatry, 78(5), 481–489. https://doi.org/10.1001/jamapsychiatry.2020.3285
Carhart-Harris, R., Giribaldi, B., Watts, R., Baker-Jones, M., Murphy-Beiner, A., Murphy, R., Martell, J., Blemings, A., Erritzoe, D., & Nutt, D. J. (2021). Trial of psilocybin versus escitalopram for depression. New England Journal of Medicine, 384(15), 1402–1411. https://doi.org/10.1056/NEJMoa2032994
Shao, L. X., Liao, C., Bhatt, D. L., & Bhatt, D. (2021). Psilocybin induces rapid and persistent growth of dendritic spines in frontal cortex in vivo. Neuron, 109(16), 2535–2544. https://doi.org/10.1016/j.neuron.2021.06.008
Shop Related Spores
Laboratory-grade Psilocybe cubensis spore syringes for microscopy research.