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Lion's Mane & Depression: What the Research Actually Shows
An evidence-based look at whether Lion's Mane mushroom may help with depression, and how its effects on nerve growth factor (NGF) might work in the brain.
lion's manehericium erinaceusdepressionNGFnerve growth factormental healthfunctional mushrooms
Source Research Papers
Citations in APA 7 format. All studies were sourced from peer-reviewed journals via Google Scholar.
Chong, P. S., Fung, M.-L., Wong, K. H., & Lim, L. W. (2020). Therapeutic potential of Hericium erinaceus for depressive disorder. International Journal of Molecular Sciences, 21(1), Article 163. https://doi.org/10.3390/ijms21010163
🔵 ReviewMixed / unclear
Bottom line
Lays out why Lion's Mane might help depression — by spurring nerve growth rather than changing brain chemicals — while stressing it hasn't been tested against real antidepressants in people.
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