How Psilocybin's Mystical Experiences Treat Depression: Mechanisms Explained
A podcast unpacking the proposed mechanism by which psilocybin-occasioned mystical experiences produce antidepressant effects — covering disruption of the default mode network, emotional processing changes measured by fMRI, and why the intensity of the mystical experience predicts the magnitude of antidepressant response.
Content Coming Soon
This resource is being prepared and will be available shortly.
Source Research Papers
Citations in APA 7 format. All studies were sourced from peer-reviewed journals via Google Scholar.
Griffiths, R. R., Richards, W. A., McCann, U., & Jesse, R. (2006). Psilocybin can occasion mystical-type experiences having substantial and sustained personal meaning and spiritual significance. Psychopharmacology, 187(3), 268–292. https://doi.org/10.1007/s00213-006-0457-5
James, E., Robertshaw, T. L., Hoskins, M., & Sessa, B. (2020). Psilocybin occasioned mystical-type experiences. Human Psychopharmacology: Clinical and Experimental, 35(5), e2742. https://doi.org/10.1002/hup.2742
Carhart-Harris, R. L., Roseman, L., Bolstridge, M., Demetriou, L., Pannekoek, J. N., Wall, M. B., Tanner, M., Kaelen, M., McGonigle, J., Murphy, K., Leech, R., Curran, H. V., & Nutt, D. J. (2017). Psilocybin for treatment-resistant depression: fMRI-measured brain mechanisms. Scientific Reports, 7, 13187. https://doi.org/10.1038/s41598-017-13282-7
Shop Related Spores
Laboratory-grade Psilocybe cubensis spore syringes for microscopy research.