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Home/Research Hub/Psilocybin & Depression: Can It Rewire the Brain?
VideoNeuroscience

Psilocybin & Depression: Can It Rewire the Brain?

An overview of how psilocybin may help with depression by changing the way brain networks work.

psilocybindepressionneuroplasticityfMRIpsychedelic therapyclinical researchpsilocybe cubensis

Source Research Papers

Citations in APA 7 format. All studies were sourced from peer-reviewed journals via Google Scholar.

Daws, R. E., Timmermann, C., Giribaldi, B., Sexton, J. D., Wall, M. B., Erritzoe, D., Roseman, L., Nutt, D., & Carhart-Harris, R. (2022). Increased global integration in the brain after psilocybin therapy for depression. Nature Medicine, 28(4), 844–851. https://doi.org/10.1038/s41591-022-01744-z

🟡 Early evidenceHow it works
Bottom line

Brain scans showed psilocybin therapy made depressed patients' brain networks more flexible and connected — a change linked to feeling better, and one not seen with a standard antidepressant.

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